When it comes to hyperhidrosis, many times you will unexpectedly think of the "stinky fox" under the armpits, but there will be excessive sweating on the palms and feet.

Perspiration is designed to regulate body temperature, remove waste and form an acidic protective layer on the skin's surface to block the invasion of germs. However, hyperhidrosis is diagnosed when sweating is excessive enough to interfere with daily life and persists for more than six months. This is due to sympathetic hyperfunction, which is genetic, emotional, or may be caused by a medical condition, such as anxiety, hyperthyroidism, nerve damage, or secondary hyperhidrosis caused by the use of certain medications. Usually secondary hyperhidrosis is generalized sweating with other symptoms.

Perspiration is controlled by the sympathetic nervous system, and when a message arrives, the nerve terminal releases the nerve transmitter acetylcholine, which stimulates the sweat glands to secrete sweat. For this reason, the injection of botulinum toxin such as Botox or Xeomin into the palm cortex can block the release of acetylcholine from the nerve endings, directly reducing the sweat secretion there, but will not affect the normal sweating function of other parts of the body. Although the treatment process is simple and quick, it should be noted that this treatment is an off-label use, and the injection is painful, and there must be sufficient anesthesia beforehand, which may also cause bruising and temporary hand weakness.